Jessalyn Rogers: 'Naturally-derived peptide nanotubes: discovery to functionalization'
Next MéDynA journal club:
Feb. 1st, 11.00 Paris time
Title: Naturally-derived peptide nanotubes: discovery to functionalization
Abstract: The natural world is a rich source of diverse and functional peptide nanotubes which form the basis of synthetic nanotube designs. Small changes in the sequences can lead to unexpected alterations in structure at all levels, leading to great diversity as we strive toward predicting assembly structure from sequence. I will present nanotubes composed of single repeat motifs from proteins found in thermophilic microbes, and concatemers of one of these, which has been successfully decorated. I will also discuss my work mining the bacterial type 4 secretion system for structures that will inform de novo protein engineers and lead to future designs.