Unité Biochimie des Interactions Macromoléculaires
Département Biologie Structurale et Chimie
UMR CNRS 3528 – Biologie Structurale & Agents Infectieux
The adenylate cyclase toxin (CyaA, 1706 residues) plays an essential role in the early stages of respiratory tract colonization by Bordetella pertussis. Our projects illustrate the structural flexibility of bacterial toxins adapted to various functions and contexts, such as protein secretion and folding, membrane translocation, enzymatic complex formation and activation. Our data opens new perspectives to improve CyaA-based applications, such as antigen delivery vehicles and vaccine against pertussis.